Fresh analysis indicates that individuals who stop using blockbuster GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds at a significantly accelerated pace than those who end conventional lifestyle plans.
Findings released in a leading medical journal shows that while overweight people frequently drop a large proportion of their total mass while on the medication, the mass comes back at an estimated rate of 0.8 kg per month once they quit.
"Individuals purchasing these drugs should be informed of the danger of quick weight regain when the treatment ends," cautioned researcher Dr. Susan Jebb.
This pace of recovery means a reversion to original weight within about a year and a half.
Comparing Therapies
The study, which examined dozens of trials involving over 9,000 of patients, contrasted the results of these new drugs with other pills.
Researchers note that people who shed pounds through dieting typically have a slower creep back—around 0.1 kg a month—once they finish.
The Reason for the Quick Rebound
Doctors believe the mechanism of the drugs accounts for the amplified rebound.
GLP-1 drugs copy a body's own chemical called GLP-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 levels far above than the body's typical production may cause the system to generate a reduced amount of its own natural hormone, and may also diminish responsiveness to its actions," noted Dr. Adam Collins, a dietetics researcher.
"Stopping of this medication results in hunger is uncontrolled, making excessive eating far more likely."
A Chronic Issue?
The NHS suggest the jabs for individuals with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Professionals argue that, given the likelihood of weight regain, the therapy should be considered ongoing.
This perspective is reinforced by drug manufacturers, who note that the findings "emphasize the persistent character of excess weight," akin to managing diseases like diabetes.
Patient Experiences
Individuals who have come off the jabs explain a sudden return of cravings.
"I experienced a switch that goes on and you become extremely hungry," said an individual.
This difficulty is worsened if users have not adopted sustainable lifestyle or habit changes during therapy.
Growing Adoption
Recent estimates show that a significant number of adults in the UK have tried weight-loss jabs in the last 12 months, with desire being substantial.
- Adoption is higher among women than males.
- The 40s and 50s demographic shows the highest usage rates.
- Many obtain the medications through private healthcare rather than the NHS.
Ultimately, experts caution that while GLP-1 drugs are potent tools for shedding pounds, they are not a magic fix and lasting health benefits likely depends on combined behavioural management.
